N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamideMS-794833

Name	BMS-794833
Synonyms	MS-794833 BMS-794833 PDYXPCKITKHFOZ-UHFFFAOYSA-N N-[4-(2-AMINO-3-CHLOROPYRIDIN-4-YL)OXY-3-FLUOROPHENYL]-5-(4-FLUOROPHENYL)-4-OXO-1H-PYRIDINE-3-CARBOXAMIDE N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide N-[4-((2-Amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 3-PyridinecarboxaMide, N-[4-[(2-aMino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo- N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide MS-794833
CAS	1174046-72-0

Molecular Formula	C23H15ClF2N4O3
Molar Mass	468.84
Density	1.508
Boling Point	637.2±55.0 °C(Predicted)
pKa	8.79±0.69(Predicted)
Storage Condition	-20℃
In vitro study	BMS794833 also inhibited Met receptor-activated gastric cancer cell line GTL-16 with an IC50 of 39 nM. BMS794833 also inhibited Met receptor-activated gastric cancer cell line GTL-16 with an IC50 of 39 nM.
In vivo study	BMS798433 treatment of human gastric xenograft model GTL-16 cell line for 14 days showed no significant cytotoxicity and tumor growth inhibition of more than 50% per tumor. BMS798433 acted on the malignant glioma model U87 and treated 25mg of BMS798433 per kg of animal body weight, which showed that the tumor completely stopped growing. BMS798433 treatment of human gastric xenograft model GTL-16 cell line for 14 days showed no significant cytotoxicity and tumor growth inhibition rate was more than 50% per tumor. BMS798433 acted on the malignant glioma model U87 and treated 25mg of BMS798433 per kg of animal body weight, which showed that the tumor completely stopped growing.

Last Update：2024-01-02 23:10:35

biological activity	BMS-794833 is an effective ATP competitive Met/VEGFR2 inhibitor, IC50 is 1.7 nM/15 nM, also inhibits Ron, Axl and Flt3,IC50 is lower than 3 nM; It is a BMS-817378 precursor drug. Phase 1. BMS-794833 is an effective ATP competitive Met (c-Met)/VEGFR2 inhibitor with IC50 of 1.7 nM/15 nM, also inhibiting Ron, Axl and Flt3,IC50 lower than 3 nM; It is a BMS-817378 prodrug. Phase 1.
in vitro study	BMS794833 also inhibited Met receptor activated gastric cancer cell line GTL-16 with IC50 of 39 nM. BMS794833 also inhibited Met receptor activated gastric cancer cell line GTL-16 with IC50 of 39 nM.
in vivo study	BMS798433 treated the GTL-16 cell line of human gastric transplant tumor model for 14 days without obvious cytotoxicity, and the tumor growth inhibition rate in each tumor reached more than 50%. BMS798433 acted on U87 malignant glioma model and treated 25mg BMS798433 per kilogram according to animal weight. The results showed that the tumor completely stopped growing. BMS798433 treatment of human gastric transplanted tumor model GTL-16 cell lines for 14 days without obvious cytotoxicity, and the tumor growth inhibition rate in each tumor reached more than 50%. BMS798433 acted on U87, a malignant glioma model, BMS798433 25mg per kilogram according to animal weight. The results showed that the tumor completely stopped growing.
target	TargetValue Met 1.7 nM VEGFR2 15 nM
Target	Value
Met	1.7 nM
VEGFR2	15 nM

Last Update：2024-04-09 21:54:55

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Product Name: BMS-794833 Visit Supplier Webpage Request for quotation
CAS: 1174046-72-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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N-[4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamideMS-794833 Request for Quotation